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In 1972, deep in the Appalachian wilderness, a bus carrying  Catholic school girls and their nun chaperone, Sister Lucy, is lost and  stranded in the foreboding woods of West Virginia. The travelers are cut  off from civilization, isolated in hostile terrain. The forest harbors  dark secrets, and they are not alone.

A clan of cannibalistic  mountain men, grotesquely disfigured by generations of inbreeding, lurk  in the shadows. Driven to the brink of extinction by their own  sterility, they hunt for outsiders to sustain their bloodline, focusing  on the busload of women they believe can save them.

The girls,  unprepared and terrified, must rely on Sister Lucy's guidance to  survive. As the clan launches a brutal attack, the girls are transformed  from helpless innocents into fierce survivors. With the relentless  cannibals closing in, the battle for survival turns the forest into a  blood-soaked battleground where the line between prey and predator blurs  as each side fights desperately for their idea of family.